#50: Exploring CO2 Sensitivity in Behaviorally Inhibited Humans and Rats — Presentation Detail — Celebration of Scholars

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Abstracts must include a title and a description of the research, scholarship, or creative work. The description should be 150-225 words in length and constructed in a format or style appropriate for the presenter’s discipline.

The following points should be addressed within the selected format or style for the abstract:

A clear statement of the problem or question you pursued, or the scholarly goal or creative theme achieved in your work.
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Additional Information

More information is available at carthage.edu/celebration-scholars/. The following are members of the Research, Scholarship, and Creativity Committee who are eager to listen to ideas and answer questions:

Jun Wang
Kim Instenes
John Kirk
Nora Nickels
Andrew Pustina
James Ripley

#50: Exploring CO2 Sensitivity in Behaviorally Inhibited Humans and Rats

Name: Olivia Wolf
Major: Neuroscience and Biology
Hometown: Rochester, IL
Faculty Sponsor:
Other Sponsors:
Type of research: SURE
Funding: SURE

Abstract

Behavioral inhibition (BI) is believed to be a genetically determined trait that affects roughly 33% of the population. These individuals tend to respond to stressful situations differently than non-behaviorally inhibited (NBI) individuals. Previous studies have already displayed differences between NBI and BI individuals. A portion of this study, however, focuses on physiological responses to increasing levels of CO through an analyses of breathing, heart rate, and blood pressure in BI and NBI populations. At 3%, 5%, and 7% CO, respectively, a slope (inspired minute ventilation (L/min) / %CO revealed that BI individuals have increased, exaggerated responses to the respiratory stressor. In the rodent population, a similar behavioral/stress model exists. The Sprague-Dawley (SD) strain often acts as a “control’ among rat strains and can be considered to be the rat equivalent to NBI individuals. On the other hand, the stressed Wistar-Kyoto (WKY) strain is the rodent equivalent to BI individuals. Using a custom-built plethysmograph to measure heart rate and breathing in the rodent population, we predict that the stressed, WKY, population will model a similar behavior to BI individuals upon exposure to increasing levels of CO.

Poster file