#35: Synthesis of Amino Acid Surfactants to Examine Antimicrobial Properties — Presentation Detail — Celebration of Scholars

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Jun Wang
Kim Instenes
John Kirk
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Andrew Pustina
James Ripley

#35: Synthesis of Amino Acid Surfactants to Examine Antimicrobial Properties

Name: Cole Hanson
Major: Chemistry
Hometown: Chili, WI
Faculty Sponsor:
Other Sponsors: None
Type of research: Independent research
Funding: 2022-2023 Student Research Grant

Abstract

As bacteria continue to develop antibiotic resistant properties, the need for new antimicrobial agents increases dramatically. Amino-acid surfactants have generated interest as a possible antimicrobial agent due to their biodegradability and effectiveness against bacteria. ω-alkenyl O-linked leucine surfactants were previously synthesized and analyzed for the effectiveness against bacteria in collaboration with the Brownholland and Tobiason research groups. However, these surfactants slowly degraded due to the ester linkage between the hydrophobic chain and the leucine headgroup. In order to address this challenge, we redesigned the surfactant to contain an amide linker between the hydrophobic chain and the carboxylate end of leucine and report the progress towards this synthesis.

Poster file