Targeted nanodisks induced significant apoptosis in Mantle Cell Lymphoma cells — Presentation Detail — Celebration of Scholars

Instructions

Student presentations must have a faculty sponsor.

Abstracts must include a title and a description of the research, scholarship, or creative work. The description should be 150-225 words in length and constructed in a format or style appropriate for the presenter’s discipline.

The following points should be addressed within the selected format or style for the abstract:

A clear statement of the problem or question you pursued, or the scholarly goal or creative theme achieved in your work.
A brief comment about the significance or uniqueness of the work.
A clear description of the methods used to achieve the purpose or goals for the work.
A statement of the conclusions, results, outcomes, or recommendations, or if the work is still in progress, the results you expect to report at the event.

Presenter photographs should be head and shoulder shots comparable to passport photos.

Additional Information

More information is available at carthage.edu/celebration-scholars/. The following are members of the Research, Scholarship, and Creativity Committee who are eager to listen to ideas and answer questions:

Jun Wang
Kim Instenes
John Kirk
Nora Nickels
Andrew Pustina
James Ripley

Targeted nanodisks induced significant apoptosis in Mantle Cell Lymphoma cells

Name: Richard Stauffer
Major: Biology and Chemistry
Hometown: Round Lake, IL
Faculty Sponsor: Amareshwar Singh
Other Sponsors:
Type of research: SURE
Funding: SURE

Name: Manar Mohammad
Major: English
Hometown: Kenosha, WI
Faculty Sponsor: Amareshwar Singh
Other Sponsors:
Type of research: SURE
Funding: SURE

Abstract

Mantle cell lymphoma (MCL) is a distinct genetic subtype of B-cell Non-Hodgkin’s Lymphoma. It is genetically characterized by the t(11:14)(q13:q32) translocation leading to a constitutive expression of cyclin D1, facilitating deregulation of cell cycle at G1-S phase transition. There is currently no standard therapy for newly diagnosed or relapsed disease. New treatment approaches are needed that target novel biologic pathways. Since nanotechnology serves as a valuable tool for cancer therapies, we used a formulation of All Trans Retinoic Acid (ATRA)/Curcumin in nanoparticles (termed nanodisks, ND). The nanodisks were scaffolded with a fusion protein comprising scFv against CD20 and apoA1, to provide targeting to the MCL cells which predominantly express CD20. We assessed the relative ability of these novel targeted drug delivery agents to induce apoptosis in MCL, as well as in cells demonstrating a neoplasm of follicle center B (HF-1), using annexin/propidium iodide flow cytometry. Our data show that curcumin-ND induced cell death more effectively than ATRA-ND, or with untreated cells. Furthermore, a combination of curcumin-ND and ATRA-ND enhanced the biological activity of these drugs significantly compared to individual treatments. In summary, we determined the effects on cell death through an effective targeted drug delivery approach, via nanoparticles, to MCL cancer cells.

Poster file