Celebration of Scholars
Determining Appropriate Levels of Transdermal Stimulation for Use in an Escape/Avoidance Task
Name:
Kevin Dunn
Major: Biology
Hometown: Madison, WI
Faculty Sponsor:
Paul Martino
Other Sponsors:
Type of research: Course project
Name:
Alexandra Arber
Major: Neuroscience, Psychology
Hometown: McHenry, IL
Faculty Sponsor:
Paul Martino
Other Sponsors:
Type of research: Course project
Abstract
Behavioral inhibition (BI) is believed to be a genetically determined trait that affects about 33% of the population and is a risk factor for many anxiety disorders. These individuals respond to stressful situations differently than non-behaviorally inhibited (non-BI) individuals. Prior research on Wistar-Kyoto rats has shown significant differences in avoidance behaviors between BI and non-BI rats. The purpose of this current study is to determine appropriate voltages of low, medium, and high levels of stimulation to be used in a future study where avoidance behavior will be studied in BI and non-BI human participants. As part of the current laboratory-based study, eight transdermal stimulations of varying magnitude were delivered to human participants in random order between 30-100 mV in 10 mV intervals for each participant. Participants were asked to rate the stimulation intensity levels, ranging from 1 (barely perceptible) to 10 (extremely perceptible). From these intensity ratings, we determined that the appropriate levels of stimulation would be 50 mV which was rated 3.75 +/- 1.53, 70 mV which was rated 6.38 +/- 1.31, and 90 mV which was rated 7.38 +/- 1.54. These stimulation levels will be used in a future study that will further uncover the behavioral differences between BI and non-BI individuals. Determining these behavioral differences will contribute to furthering our understanding of psychiatric disorders like anxiety and PTSD.